The youngest of 25 children, Catherine of Siena's twin sister died immediately after their birth. Catherine grew up caring for the poor, even going so far as to provide them wine from her father's best cask. She also tried to end urban violence between family feuds and was an advisor to the Pope. in 1375 she received the five wounds of the stigmata, which were only visible to herself until after her death.
Catherine's mummified head is still preserved in the Basilica Cateriniana San Domenico in Siena.